Hb L-Persian Gulf	alpha57(E6)Gly->Arg

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		The slowly-moving variant separates from Hb A at alkaline pH; the two Hbs do not separate at low pH; Hb X moves between Hb S and Hb G on starch gel and paper
CHROMATOGRAPHY		Hb X was isolated on a DEAE-Sephadex column
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation GGC->CGC; alpha2 or alpha1
FUNCTIONAL STUDIES		Not reported
STABILITY		Normal
OCCURRENCE		Found in a female living near the Persian Gulf
OTHER INFORMATION		Quantity in the heterozygote about 18%

REFERENCES
1.		Rahbar, S., Kinderlerer, J.L., and Lehmann, H.: Acta Haematol., 42:169, 1969.

---

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.