Hb Kurdistan	alpha47(CE5)Asp->Tyr

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH
CHROMATOGRAPHY		Hb X was isolated by anion exchange chromatography
STRUCTURE STUDIES		Tryptic peptides of the alpha chain were separated by reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES		Mutation in the alpha2 gene: GAC->TAC at codon 47
FUNCTIONAL STUDIES		Not reported
STABILITY		Normal
OCCURRENCE		Found in three members of a Kurdish family
OTHER INFORMATION		Quantity in heterozygotes 17-18%; quantity of Hb X in one member who was also heterozygous for betao-thal was a low 4.2%, indicating a decreased affinity of alphaX for beta

REFERENCES
1.		Giordano, P.C., Harteveld, C.L., Streng, H., Oosterwijk, J.C., Heister, J.G.A.M., Amons, R., and Bernini, L.F.: Hemoglobin, 18:11, 1994.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.