Hb Kawachi	alpha44(CE2)Pro->Arg

CONTACT		External
HEMATOLOGY		Not reported
ELECTROPHORESIS		Hb A and Hb X separate at alkaline pH; Hb X is present between Hb A2 and Hb A on IEF
CHROMATOGRAPHY		Hb X was isolated on a DEAE-cellulose column
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation CCG->CGG; alpha2 or alpha1
FUNCTIONAL STUDIES		Increased oxygen affinity, reduced Bohr effect and cooperativity
STABILITY		Normal
OCCURRENCE		Found in three members of a Japanese family
OTHER INFORMATION		Quantity in heterozygotes 26-27%

REFERENCES
1.		Harano, T., Harano, K., Ueda, S., Shibata, S., Imai, K., Ohba, Y., Shinohara, T., Horio, S., Nishioka, K., and Shirotani, H.: Hemoglobin, 6:43, 1982.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.