Hb J-Toronto | alpha5(A3)Ala->Asp |
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CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Separates as a fast-moving Hb J from Hb A at alkaline pH | ||
CHROMATOGRAPHY | Hb X can be separated from Hb A by cation and anion exchange chromatography | ||
STRUCTURE STUDIES | Hb X was identified by fingerprinting; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation GCC->GAC; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Normal | ||
OCCURRENCE | In two English families | ||
OTHER INFORMATION | Quantity in heterozygotes 25-35% |
REFERENCES | |||
1. | Crookston, J.H., Beale, D., Irvine, D., and Lehmann, H.: Nature, 208:1059, 1965. | ||
2. | Vella, F., Hill, J.R., Wiltshire, B., and Lehmann, H.: Clin. Biochem., 4:137, 1971. |