Hb J-Medellin	alpha22(B3)Gly->Asp

CONTACT		External
HEMATOLOGY		Not reported
ELECTROPHORESIS		Hb X moves faster than Hb J at alkaline pH
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation GGC->GAC; alpha2 or alpha1
FUNCTIONAL STUDIES		Not reported
STABILITY		Not reported
OCCURRENCE		Found in two families from Colombia
OTHER INFORMATION		Quantity in heterozygotes 20%

REFERENCES
1.		Gottlieb, A.J., Restrepo, A., and Itano, H.A., Fed. Proc., 23:172, 1964.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.