Hb J-Kurosh	alpha19(AB1)Ala->Asp

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X moves to the position of Hb J on cellulose acetate and starch gel
CHROMATOGRAPHY		Hb X was isolated by DEAE-Sephadex chromatography
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis of selected peptides
DNA ANALYSES		Not reported; presumed mutation GCG->? (undefined); GCC-> GAC?; alpha2 or alpha1
FUNCTIONAL STUDIES		Not reported
STABILITY		Not reported
OCCURRENCE		Found in a healthy Iranian male
OTHER INFORMATION		Quantity in the heterozygote 25%
NOTE		Codon 19 is presumed to be GCG but may be GCC in some populations; a one base change of GCC can result in GAC and explain the Ala->Asp replacement

REFERENCES
1.		Rahbar, S., Ala, F., Akhavan, E., Nowzari, G., Shoa'i, I., and Zamanianpoor, M.H.: Biochim. Biophys. Acta, 427:119, 1976.

---

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.