Hb J-Habana	alpha71(E20)Ala->Glu

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		This fast-moving variant separates from Hb A at alkaline pH; Hb X moves to the position of Hb J-Baltimore on paper
CHROMATOGRAPHY		Hb X was isolated on a DEAE-Sephadex column
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting and reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation GCG->GAG; alpha2 or alpha1
FUNCTIONAL STUDIES		Normal
STABILITY		Normal
OCCURRENCE		Found in a Cuban family and a few Japanese families
OTHER INFORMATION		Quantity in heterozygotes ~20%

REFERENCES
1.		Colombo, B., Vidal, H., Kamuzora, H., and Lehmann, H.: Biochim. Biophys. Acta, 351:1, 1974.
2.		Ohba, Y., Yoshinaka, H., Hattori, Y., Matsuoka, M., and Miyaji, T.: Hemoglobin, 7:327, 1983.
3.		Hidaka, K., Iuchi, I., Shimasaki, S., Mizuta, W., Takatsuka, M., Mori, T., Tohdoh, A., and Matsuo, M.: Hemoglobin, 10:65, 1986.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.