Hb Iwata	alpha87(F8)His->Arg

CONTACT		Heme contact; proximal histidine
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X moves slower than Hb A on starch gel and cellulose acetate at alkaline pH
CHROMATOGRAPHY		Hb X was isolated on a DE-52 cellulose column
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation CAC->CGC; alpha2 or alpha1
FUNCTIONAL STUDIES		Not reported
STABILITY		Mildly unstable
OCCURRENCE		Found in Japanese and Chinese families
OTHER INFORMATION		Quantity in heterozygotes 5-10%; abnormal spectrum of oxy-Hb; spectrum of cyan-ferriHb is normal; variant carries two heme groups/tetramer

REFERENCES
1.		Ohba, Y., Miyaji, T., Hattori, Y., Fuyuno, K., and Matsuoka, M.: Hemoglobin, 4: 307, 1980.
2.		Liu, G-Y., Zhang, G-X., Nie, S-Y., Luo, H-Y., Teng, Y-Q., Liu, S-P., Song, M., Son, L., Chen, S-S., Jia, P-C., and Liang, C-C.: Hemoglobin, 7:279, 1983.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.