Hb Hobart | alpha20(B1)His->Arg |
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CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X separates from Hb A as a slowly-moving band at alkaline pH; its mobility is similar to that of Hb Lepore or Hb S | ||
CHROMATOGRAPHY | Hb X was isolated on a DEAE-Sephadex column | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation CAC->CGC; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Normal | ||
OCCURRENCE | Found in a family of British nationality | ||
OTHER INFORMATION | Quantity in the heterozygote 16-18% |
REFERENCES | |||
1. | Fleming, P.J., Sumner, D.R., Wyatt, K., Hughes, W.G., Melrose, W.D., Jupe, D.M.D., and Baikie, M.J., Hemoglobin, 11:211, 1987. |