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CONTACT | |
External | |
HEMATOLOGY | |
Normal in the heterozygote | |
ELECTROPHORESIS | |
Hb X moves slightly slower than Hb A on paper at alkaline pH (8.9); it moves to the position of Hb G on cellulose acetate (pH 9.0) | |
CHROMATOGRAPHY | |
Hb X was isolated on a DEAE-Sephadex column | |
STRUCTURE STUDIES | |
Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; sequencing of a few selected peptides | |
DNA ANALYSES | |
Not reported; presumed mutation GGC->CGC; alpha2 or alpha1 | |
FUNCTIONAL STUDIES | |
Not reported | |
STABILITY | |
Normal | |
OCCURRENCE | |
Found in an Indian family, a Chinese family, and a Saudi newborn | |
OTHER INFORMATION | |
Quantity in heterozygotes: 9-11% (Indian), 32% (Chinese), and 20.8% (Saudi newborn) | |
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REFERENCES |
1. | |
Griffiths, K.D., Lang, A., Lehmann, H., Mann, J.R., Plowman, D., and Raine, D.N.: FEBS Lett., 75:93, 1977. | |
2. | |
Liang, C-C., Tao, H-N., and Chang, K-F.: Hemoglobin, 5:191, 1981. | |
3. | |
Al-Awamy, B.H., Niazi, G.A., Naeem, M.A., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 9:183, 1985. | |