Hb Handsworth	alpha18(A16)Gly->Arg

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X moves slightly slower than Hb A on paper at alkaline pH (8.9); it moves to the position of Hb G on cellulose acetate (pH 9.0)
CHROMATOGRAPHY		Hb X was isolated on a DEAE-Sephadex column
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; sequencing of a few selected peptides
DNA ANALYSES		Not reported; presumed mutation GGC->CGC; alpha2 or alpha1
FUNCTIONAL STUDIES		Not reported
STABILITY		Normal
OCCURRENCE		Found in an Indian family, a Chinese family, and a Saudi newborn
OTHER INFORMATION		Quantity in heterozygotes: 9-11% (Indian), 32% (Chinese), and 20.8% (Saudi newborn)

REFERENCES
1.		Griffiths, K.D., Lang, A., Lehmann, H., Mann, J.R., Plowman, D., and Raine, D.N.: FEBS Lett., 75:93, 1977.
2.		Liang, C-C., Tao, H-N., and Chang, K-F.: Hemoglobin, 5:191, 1981.
3.		Al-Awamy, B.H., Niazi, G.A., Naeem, M.A., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 9:183, 1985.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.