Hb Handa	alpha90(FG2)Lys->Met

ALSO KNOWN AS		Munakata
CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X moves ahead of Hb A on starch gel at alkaline pH; moves anodally to Hb A on IEF
CHROMATOGRAPHY		Hb X was isolated on a DEAE-cellulose column
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting or reversed phase HPLC; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation AAG->ATG; alpha2 or alpha1
FUNCTIONAL STUDIES		Normal oxygen affinity, Bohr effect, and cooperativity
STABILITY		Normal
OCCURRENCE		Found in Japanese families
OTHER INFORMATION		Quantity in the heterozygote 17-19%

REFERENCES
1.		Harano, T., Harano, K., Shibata, S., Ueda, S., Imai, K., and Seki, M.: Hemoglobin, 6:379, 1982.
2.		Sugihara, J., Imamura, T., Kagimoto, M., Matsuo, T., Yamada, H., Imoto, T., and Yanase, T.: Biochim. Biophys. Acta, 744:119, 1983.
3.		Hidaka, K., Iuchi, I., Shimasaki, S., Mizuta, W., Takatsuka, M., Mori, T., Tohdoh, A., and Matsuo, M.: Hemoglobin, 10:65, 1986.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.