Hb Guangzhou-Hangzhou	alpha64(E13)Asp->Gly

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH; Hb X moves between Hb A and Hb A2
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation GAC->GGC; alpha2 or alpha1
FUNCTIONAL STUDIES		Slightly increased oxygen affinity
STABILITY		Normal
OCCURRENCE		Found in two apparently unrelated Chinese families
OTHER INFORMATION		Quantity in heterozygotes 19-22%

REFERENCES
1.		Jen, P.C. and Liu, Y.: Hemoglobin, 11:25, 1987.
2.		Zhou, Z-Q., Chen, L-C., Chen, P-F., Zhang, K-Q., and Wang, Y-H.: Hemoglobin, 11:31, 1987.

---

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.