Hb Guangzhou-Hangzhou | alpha64(E13)Asp->Gly |
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CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X and Hb A separate at alkaline pH; Hb X moves between Hb A and Hb A2 | ||
CHROMATOGRAPHY | Not reported | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; sequencing | ||
DNA ANALYSES | Not reported; presumed mutation GAC->GGC; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Slightly increased oxygen affinity | ||
STABILITY | Normal | ||
OCCURRENCE | Found in two apparently unrelated Chinese families | ||
OTHER INFORMATION | Quantity in heterozygotes 19-22% |
REFERENCES | |||
1. | Jen, P.C. and Liu, Y.: Hemoglobin, 11:25, 1987. | ||
2. | Zhou, Z-Q., Chen, L-C., Chen, P-F., Zhang, K-Q., and Wang, Y-H.: Hemoglobin, 11:31, 1987. |