Hb G-Honolulu | alpha30(B11)Glu->Gln |
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ALSO KNOWN AS | G-Singapore; G-Chinese; G-Hong Kong | ||
CONTACT | alpha1beta1 contact | ||
HEMATOLOGY | Normal in heterozygotes | ||
ELECTROPHORESIS | Hb X moves about as Hb S at alkaline pH; no separation at acidic pH | ||
CHROMATOGRAPHY | Hb X separates from Hb A on cation and anion exchange HPLC | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting or reversed phase HPLC; amino acid analysis; sequencing | ||
DNA ANALYSES | Not reported; presumed mutation GAG->CAG; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Not reported | ||
OCCURRENCE | Found in several Chinese families | ||
OTHER INFORMATION | Quantity in heterozygotes 12-15% |
REFERENCES | |||
1. | Vella, F., Ager, J.A.M., and Lehmann, H.: Nature, 182:460, 1958. | ||
2. | Schneider, R.G. and Jim, R.T.S.: Nature, 190:454, 1961. | ||
3. | Swenson, R.T., Hill, R.L., Lehmann, H., and Jim, R.T.S.: J. Biol. Chem., 237: 1517, 1962. | ||
4. | Zeng, Y.T., Huang, S.Z., Zhou, X.D., Feng, J.P., Chen, M.J., Sheng, M., Qiu, X.K., Tao, Y.J., Chen, B.F., Lam, H., Wilson, J.B., and Huisman, T.H.J.: Shanghai Med. J., 5:125, 1982. |