Hb Fort de France	alpha45(CE3)His->Arg

CONTACT		External; heme contact
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH (moves as Hb S on cellulose acetate); good separation by IEF
CHROMATOGRAPHY		Hb X was isolated on a DEAE-Sephadex column
STRUCTURE STUDIES		Tryptic digestion; peptides were separated by fingerprinting or cation exchange chromatography; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation CAC->CGC; alpha2 or alpha1
FUNCTIONAL STUDIES		Increased oxygen affinity; normal Bohr effect and cooperativity
STABILITY		Unstable
OCCURRENCE		Found in two unrelated families living in Martinique
OTHER INFORMATION		Quantity in the heterozygote 20%; increased autoxidation

REFERENCES
1.		Braconnier, F., Gacon, G., Thillet, J., Wajcman, H., Soria, J., Maigret, P., Labie, D., and Rosa, J.: Biochim. Biophys. Acta, 493:228, 1977.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.