Hb Davenport | alpha78(EF7)Asn->His |
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CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X moves between Hb A and Hb F on IEF | ||
CHROMATOGRAPHY | Separation was obtained by cation exchange HPLC | ||
STRUCTURE STUDIES | Tryptic peptides were separated by reversed phase HPLC; amino acid analysis; sequencing | ||
DNA ANALYSES | An AAC->CAC mutation at codon 78 in the alpha1 gene (Ref. 2) | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Normal | ||
OCCURRENCE | Found in a Caucasian family of German descent | ||
OTHER INFORMATION | Quantity in heterozygotes 19.5-21% |
REFERENCES | |||
1. | Wilson, J.B., Webber, B.B., Plaseska, D., de Alarcon, P.A., McMillan, S.K., and Huisman, T.H.J.: Hemoglobin, 14:599, 1990. | ||
2. | Molchanova, T.P., Pobedimskaya, D.D., and Huisman, T.H.J.: Br. J. Haematol., 88:300, 1994. |