Hb Dallas	alpha97(G4)Asn->Lys

CONTACT		Heme contact
HEMATOLOGY		Mild erythrocytosis in the heterozygote
ELECTROPHORESIS		Hb X moves between Hb A and Hb F on cellulose acetate at alkaline pH; moves slightly anodic to Hb S on citrate agar at acidic pH
CHROMATOGRAPHY		Hb X and Hb A can be separated by cation and anion exchange HPLC
STRUCTURE STUDIES		Tryptic peptides were separated with an HPLC procedure; amino acid analysis
DNA ANALYSES		An AAC->AAA mutation at codon 97 of the alpha2 gene (Ref. 2)
FUNCTIONAL STUDIES		Increased oxygen affinity; normal Bohr, 2,3-DPG, and IHP effects
STABILITY		Stable
OCCURRENCE		Found in a few Caucasian families in the Mid-West (USA)
OTHER INFORMATION		Quantity in heterozygotes 22-23%

REFERENCES
1.		Dysert, P.A., II, Head, C.G., Shih, T-B., Jones, R.T., and Schneider, R.G.: Blood, 60:53a (Suppl. 1), 1982.
2.		Molchanova, T.P., Pobedimskaya, D.D., and Huisman, T.H.J.: Br. J. Haematol., 88:300, 1994.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.