Hb Dagestan | alpha60(E9)Lys->Glu |
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CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X and Hb A separate at alkaline pH; the variant is fast-moving (position of Hb I on starch gel) | ||
CHROMATOGRAPHY | Not reported | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; sequencing | ||
DNA ANALYSES | Not reported; presumed mutation AAG->GAG; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Normal | ||
OCCURRENCE | Found in a female from Dagestan | ||
OTHER INFORMATION | Quantity in the heterozygote estimated at 30% |
REFERENCES | |||
1. | Spivak, V.A., Molchanova, T.P., Ermakov, N.V., Tokarev, Yu.N., Martinez, G., Szelenyi, Ju., Horanyi, M., Foldi, J., Hollan, S., Kazieva, H., and Shamov, I.A.: Hemoglobin, 5:133, 1981. |