Hb Contaldo	alpha103(G10)His->Arg

CONTACT		alpha1beta1 contact
HEMATOLOGY		Moderate hemolytic anemia in the heterozygote
ELECTROPHORESIS		Hb X moves like Hb F at alkaline pH, between Hb S and Hb C on citrate agar at acidic pH, and close to Hb F on IEF
CHROMATOGRAPHY		Hb X was isolated by DEAE-cellulose chromatography
STRUCTURE STUDIES		Tryptic peptides of the oxidized alphaX chain were separated by reversed phase HPLC; amino acid analysis; sequence analyses of the core peptide
DNA ANALYSES		Not reported; presumed mutation CAC->CGC; alpha2 or alpha1
FUNCTIONAL STUDIES		Not reported
STABILITY		Unstable
OCCURRENCE		Found in an Italian child
OTHER INFORMATION		Quantity in the heterozygote 15-20%

REFERENCES
1.		Sciarratta, G.V., Ivaldi, G., Molaro, G.L., Sansone, G., Salkie, M.L., Wilson, J.B., Reese, A.L., and Huisman, T.H.J.: Hemoglobin, 8:169, 1984.

---

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.