Hb Bourmedès | alpha37(C2)Pro->Arg |
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CONTACT | Internal | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X separates from Hb A at alkaline pH; its mobility is between Hb S and Hb A2; excellent separation by IEF | ||
CHROMATOGRAPHY | Not reported | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting or reversed phase HPLC; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation CCC->CGC; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not studied | ||
STABILITY | Not studied | ||
OCCURRENCE | Found in an Algerian family; the proband was also homozygous for Hb S | ||
OTHER INFORMATION | Quantity in the heterozygote 16-20% |
REFERENCES | |||
1. | Dahmane-Arbane, M., Blouquit, Y., Arous, N., Bardakdjian, J., Benamani, M., Riou, J., Benabadji, M., Rosa, J., and Galacteros, F.: Nouv. Rev. Fr. d'Hematol., 29:317, 1987. |