Hb Aztec	alpha76(EF5)Met->Thr

CONTACT		Internal
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		No separation observed at alkaline and acidic pH
CHROMATOGRAPHY		Hb X and Hb A apparently do not separate by cation or anion exchange HPLC; the variant was detected as an abnormal alpha chain by reversed phase HPLC
STRUCTURE STUDIES		Tryptic peptides were separated by reversed phase HPLC; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation ATG->ACG; alpha2 or alpha1
FUNCTIONAL STUDIES		Normal
STABILITY		Not reported
OCCURRENCE		Found in a newborn and her mother of native Mexican and Spanish descent
OTHER INFORMATION		None

REFERENCES
1.		Shelton, J.B., Shelton, J.R., Schroeder, W.A., and Powars, D.R: Hemoglobin, 9:325, 1985.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.