Hb Arya | alpha47(CE5)Asp->Asn |
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CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X and Hb A separate at alkaline pH but not at acidic pH; moves with Hb S on cellulose acetate; moves as Hb S on starch gel | ||
CHROMATOGRAPHY | Hb X was isolated on a DEAE-cellulose column | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; sequencing | ||
DNA ANALYSES | Not reported; presumed mutation GAC->AAC; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Slightly unstable | ||
OCCURRENCE | Found in an Iranian family | ||
OTHER INFORMATION | Quantity in heterozygotes 22% |
REFERENCES | |||
1. | Rahbar, S., Mahdavi, N., Nowzari, G., and Mostafavi, I.: Biochim. Biophys. Acta, 386:525, 1975. |