Hb Nakano | beta8(A5)Lys->Met |
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CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X moves faster than Hb A on IEF | ||
CHROMATOGRAPHY | Hb X and Hb A separate on anion exchange HPLC columns; the betaX chain elutes ahead of betaA from a CM-cellulose column | ||
STRUCTURE STUDIES | Tryptic digestion of AE-betaX chain; separation of peptides by reversed phase HPLC; amino acid analysis; sequencing | ||
DNA ANALYSES | Not reported; presumed mutation AAG->ATG at codon 8 | ||
FUNCTION STUDIES | Not reported | ||
STABILITY | Normal | ||
OCCURRENCE | Found in a 46-year-old Japanese woman | ||
OTHER INFORMATION | Quantity in the heterozygote 45.3% |
REFERENCES | |||
1. | Harano, K., Harano, T., Koide, G., and Akimaru, S.: Hemoglobin, 19:397, 1995. |