Hb Boyle Heights | alpha6(A4)Asp->0 |
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HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X moves between Hb S and Hb F at alkaline pH, and with Hb A at acidic pH | ||
CHROMATOGRAPHY | Hb X and Hb A separate on a DEAE-cellulose column | ||
STRUCTURE STUDIES | Tryptic digestion of Hb X; separation of peptides by reversed phase HPLC; amino acid analysis | ||
DNA ANALYSES | Not reported | ||
FUNCTION STUDIES | Increased oxygen affinity | ||
STABILITY | Unstable | ||
OCCURRENCE | Found in members of a Mexican family | ||
OTHER INFORMATION | Quantity in the heterozygote 14% |
REFERENCES | |||
1. | Johnson, C.S., Schroeder, W.A., Shelton, J.B., and Shelton, J.R.: Hemoglobin, 7:125, 1983. | ||
2. | Zhao, W., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 14:637, 1990. |