VARIANTS OF THE DELTA CHAIN (single base changes)

Hb Name        Residue
       Amino Acid
       Mutation (mutations in
parentheses are presumed)
A2-Niigata 1(NA1) Val->Ala (GTG->GCG)
A2-Sphakiá 2(NA2) His->Arg (CAC->CGC)
A2-NYU 12(A9) Asn->Lys (AAT->AAA)
A2' (or B2) 16(A13) Gly->Arg GGC->CGC
A2-Roosevelt 20(B2) Val->Glu (GTG->GAG)
A2-Flatbush 22(B4) Ala->Glu (GCA->GAA)
A2-Victoria 24(B6) Gly->Asp (GGT->GAT)
A2-Yokoshima 25(B7) Gly->Asp (GGT->GAT)
A2-Puglia 26(B8) Glu->Asp GAG->GAC
A2-Yialousa 27(B9) Ala->Ser GCC->TCC
A2-Melbourne 43(CD2) Glu->Lys (GAG->AAG)
A2-Agrinio 43(CD2) Glu->Gly GAG->GGG
A2-Parkville 47(CD6) Asp->Val (GAT->GTT)
A2-Adria 51(D2) Pro->Arg (CCT->CGT)
A2-Indonesia 69(E13) Gly->Arg (GGT->CGT)
A2-Grovetown 75(E19) Leu->Val CTG->GTG
A2-Honai 90(F6) Glu->Val (GAG->GTG)
A2-Sant' Antioco 93(F9) Cys->Gly TGT->GGT
A2-Wrens 98(FG5) Val->Met GTG->ATG
A2-Canada 99(G1) Asp->Asn (GAT->AAT)
A2-Coburg 116(G18) Arg->His (CGT->CAT)
A2-Troodos 116(G18) Arg->Cys CGC->TGC
A2-Liangcheng 117(G19) Asn->Asp AAC->GAC
A2-Manzanares 121(GH4) Glu->Val (GAA->GTA)
A2-Zagreb 125(H3) Gln->Glu (CAA->GAA)
A2-Babinga 136(H14) Gly->Asp (GGT->GAT)
A2-Pelendri 141(H19) Leu->Pro CTG->CCG
A2-Fitzroy 142(H20) Ala->Asp (GCC->GAC)

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.