Hb P-Galveston beta117(G19)His->Arg
         
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A separate at alkaline pH (Hb X moves in the position of Hb S) but not at acidic pH
CHROMATOGRAPHY Hb X and Hb A can be separated by both cation and anion exchange chromatography
STRUCTURE STUDIES Tryptic digestion of AE-betaX chain; separation of peptides by fingerprinting or by cation exchange chromatography; amino acid analysis
DNA ANALYSES Not reported; presumed mutation CAC->CGC at codon 117
FUNCTION STUDIES Normal
STABILITY Normal
OCCURRENCE Found in several Black families
OTHER INFORMATION Quantity in heterozygotes 45-50%; found in combination with Hb S, with Hb C, and with beta-thal
       
REFERENCES
1. Dherte, P., Lehmann, H., and Vandepitte, J.: Nature, 184:1133, 1959.
2. Silvestroni, E., Bianco, I., and Brancati, C.: Nature, 191:292, 1961.
3. Schneider, R.G., Alperin, J.B., Brimhall, B., and Jones, R.T.: J. Lab. Clin. Med., 73:616, 1969.
4. Di Iorio, E.E., Winterhalter, K.H., Wilson, K., Rosenmund, A., and Marti, H.R.: Blut, 31:61, 1975.
5. Huisman, T.H.J.: FEBS Lett., 94:68, 1978.


This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.