Hb Okayama	beta2(NA2)His->Gln

CONTACT		2,3-DPG binding site
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X and Hb A can be separated by IEF; Hb X moves as Hb A1c
CHROMATOGRAPHY		Hb X was isolated by cation exchange chromatography
STRUCTURE STUDIES		Tryptic digestion; fingerprinting; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation CAC->CAA or CAG at codon 2
FUNCTION STUDIES		Slight increase in oxygen affinity
STABILITY		Normal
OCCURRENCE		Found in a diabetic Japanese male
OTHER INFORMATION		Quantity in the heterozygote 47.4%

REFERENCES
1.		Harano, T., Harano, K., Shibata, S., Ueda, S., Mori, H., and Arimasa, N.: FEBS Lett., 156:20, 1983.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.