Hb N-Baltimore beta95(FG2)Lys->Glu
ALSO KNOWN AS Hopkins-I; Jenkins; N-Memphis; Kenwood
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A separate at alkaline pH; Hb X is one of the fastest moving beta chain variants; excellent separation by IEF
CHROMATOGRAPHY Hb X and Hb A separate by both cation and anion exchange chromatography
STRUCTURE STUDIES Tryptic digestion of AE-betaX chain; separation of peptides by fingerprinting; cation exchange chromatography; reversed phase HPLC; amino acid analysis
DNA ANALYSES An AAG->GAG mutation at codon 95
FUNCTION STUDIES Normal oxygen affinity
OCCURRENCE Found in numerous Black families in the SE-USA
OTHER INFORMATION Quantity in the heterozygotes 44-54%; found in combination with Hb C and also with Hb S
1. Clegg, J.B., Naughton, M.A., and Weatherall, D.J.: Nature, 207:945, 1965.
2. Dobbs, N.B., Simmons, J.W., Wilson, J.B., and Huisman, T.H.J.: Biochim. Biophys. Acta, 117:492, 1966.
3. Fuller, R.W. and Hunt, J.M.: Nature, 214:189, 1967.
4. Johnson, C., Powars, D., and Schroeder, W.A.: Acta Haematol., 56:183, 1976.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.