Hb Minneapolis-Laos | beta118(GH1)Phe->Tyr |
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CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | IEF revealed an extra band with a mobility like Hb F | ||
CHROMATOGRAPHY | Hb X and Hb A can be separated on a DEAE-cellulose or a DEAE-Sephadex column | ||
STRUCTURE STUDIES | After aminoethylation, the betaX was digested with trypsin and the resulting fragments separated by reversed phase HPLC; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation TTT->TAT at codon 118 | ||
FUNCTION STUDIES | Normal | ||
STABILITY | Normal | ||
OCCURRENCE | Found in a 27-year-old Laotian male and a 1-year-old Cambodian male and his mother | ||
OTHER INFORMATION | Quantity in the heterozygote ~45% |
REFERENCES | |||
1. | Hedlund, B., Paine, S., Smith, C.M., II, Raines, J., Morrison, W.T., and Adams, J., III: Hemoglobin, 8:75, 1984. | ||
2. | Kleman, K., Lubin, B., Kutlar, A., Wilson, J.B., Webber, B.B., and Huisman, T.H.J.: Hemoglobin, 11:401, 1987. |