Hb Denver	beta41(C7)Phe->Ser

CONTACT		Heme contact
HEMATOLOGY		Normal to mild anemia in the heterozygote; cyanosis
ELECTROPHORESIS		No separation obtained at alkaline pH or by IEF
CHROMATOGRAPHY		No separation reported
STRUCTURE STUDIES		No details reported
DNA ANALYSES		Not reported; presumed mutation TTC->TCC at codon 41
FUNCTION STUDIES		Decreased oxygen affinity
STABILITY		Unstable
OCCURRENCE		Found in members of a Caucasian family
OTHER INFORMATION		None; quantity in the heterozygote not determined

REFERENCES
1.		Stabler, S., Jones, R.T., Head, C, Shih, D.T.B., and Fairbanks, V.F.: Blood, 82: 229a (Suppl. 1), 1993.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.