Hb Yuda alpha130(H13)Ala->Asp
CONTACT Internal; central cavity
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X has a pI nearly the same as Hb A1c on IEF
STRUCTURE STUDIES The alphaX chain was isolated by CM-cellulose chromatography; tryptic digestion; amino acid analysis; sequencing
DNA ANALYSES Not reported; presumed mutation GCT->GAT; alpha2 or alpha1
FUNCTIONAL STUDIES Decreased oxygen affinity
OCCURRENCE Found in a diabetic Japanese female
OTHER INFORMATION The alphaX chain accounts for ~30% of total alpha
1. Fujisawa, K., Hattori, Y., Ohba, Y., and Ando, S.: Hemoglobin, 16:435, 1992.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.