Hb Woodville alpha6(A4)Asp->Tyr
CONTACT External; partly buried
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Electrophoresis at pH 9.2 gave a slow-moving component migrating close to the position of Hb F; this band did not separate from Hb A on citrate agar electrophoresis
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES Not reported; presumed mutation GAC->TAC; alpha2 or alpha1
FUNCTIONAL STUDIES Slightly increased oxygen affinity
OCCURRENCE Found in a Vietnamese family
OTHER INFORMATION Quantity in heterozygotes 9% of total Hb
1. Como, P.F., Barber, S., Sage, R.E., and Kronenberg, H.: Abstract, 29th Meeting of the Royal College of Pathologists of Australia, Melbourne, 1983.
2. Como, P.F., Barber, S., Sage, R.E., Trent, R.J., and Kronenberg, H.: Hemoglobin, 10:135, 1986.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.