Hb Woodville | alpha6(A4)Asp->Tyr |
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CONTACT | External; partly buried | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Electrophoresis at pH 9.2 gave a slow-moving component migrating close to the position of Hb F; this band did not separate from Hb A on citrate agar electrophoresis | ||
CHROMATOGRAPHY | Not reported | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation GAC->TAC; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Slightly increased oxygen affinity | ||
STABILITY | Normal | ||
OCCURRENCE | Found in a Vietnamese family | ||
OTHER INFORMATION | Quantity in heterozygotes 9% of total Hb |
REFERENCES | |||
1. | Como, P.F., Barber, S., Sage, R.E., and Kronenberg, H.: Abstract, 29th Meeting of the Royal College of Pathologists of Australia, Melbourne, 1983. | ||
2. | Como, P.F., Barber, S., Sage, R.E., Trent, R.J., and Kronenberg, H.: Hemoglobin, 10:135, 1986. |