Hb Winnipeg alpha75(EF4)Asp->Tyr
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X moves between Hb S and Hb A on paper and starch gel; moves between Hb S and Hb F on cellulose acetate and like Hb A on citrate agar
CHROMATOGRAPHY Hb X was isolated on a DEAE-cellulose column
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting or reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES Not reported; presumed mutation GAC->TAC; alpha2 or alpha1
OCCURRENCE Found in a few Caucasian families in Canada and the United States
OTHER INFORMATION Quantity in heterozygotes 13-20%
1. Vella, F., Wiltshire, B., Lehmann, H., and Galbraith, P., Clin. Biochem., 6:66, 1973.
2. Nakatsuji, T., Abraham, B.L., Lam, H., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 7:105, 1983.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.