Hb Tokoname alpha139(HC1)Lys->Thr
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X is more anodic than Hb A by IEF
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; chymotrypsin
DNA ANALYSES Not reported; presumed mutation AAA->ACA; alpha2 or alpha1
FUNCTIONAL STUDIES Increased oxygen affinity; decreased cooperativity; normal Bohr effect
OCCURRENCE Found in a Japanese female
OTHER INFORMATION Quantity in the heterozygote about 25%
1. Harano, T., Harano, K., Shibata, S., Ueda, S., Imai, K., and Seki, M.: Hemoglobin, 7:85, 1983.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.