Hb St. Claude alpha127(H10)Lys->Thr
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X moves faster than Hb A at alkaline pH
CHROMATOGRAPHY Hb X and Hb A separate by cation and anion exchange chromatography
STRUCTURE STUDIES Tryptic digestion; separation of peptides by cation exchange chromatography; performic acid, chymotrypsin; amino acid analysis
DNA ANALYSES Not reported; presumed mutation AAG->ACG; alpha2 or alpha1
STABILITY Not reported
OCCURRENCE Found in a family of French-Canadian descent
OTHER INFORMATION Quantity in the heterozygote 27-29%
1. Vella, F., Galbraith, P., Wilson, J.B., Wong, S.C., Folger, G.C., and Huisman, T.H.J.: Biochim. Biophys. Acta, 365:318, 1974.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.