Hb Singapore | alpha141(HC3)Arg->Pro |
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CONTACT | C-terminus | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X moves to the position of Hb J-Baltimore at alkaline pH | ||
CHROMATOGRAPHY | Not reported | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; chymotrypsin | ||
DNA ANALYSES | Not reported; presumed mutation CGT->CCT; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Normal | ||
OCCURRENCE | Found in members of a family living in Singapore | ||
OTHER INFORMATION | Quantity in heterozygotes about 25% |
REFERENCES | |||
1. | Clegg, J.B., Weatherall, D.J., Wong, H.B., and Mustafa, D.: Nature, 222:379, 1969. |