Hb Shuangfeng alpha27(B8)Glu->Lys
CONTACT External; surface crevice
HEMATOLOGY Hemolytic anemia in the heterozygote
ELECTROPHORESIS Hb X moves between Hb S and Hb C on cellulose acetate (pH 8.6); moves with Hb A on citrate agar (pH 6.0)
CHROMATOGRAPHY Hb X was isolated by DE-52 cellulose chromatography
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES Not reported; presumed mutation GAG->AAG; alpha2 or alpha1
OCCURRENCE Found in six members of a Chinese family
OTHER INFORMATION Quantity in heterozygotes about 13%
1. Liang, C., Tao, H., Lo, H., Huang, S., Li, R., and Wang, B.: Hemoglobin, 5:691, 1981.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.