Hb Shimonoseki	alpha54(E3)Gln->Arg

ALSO KNOWN AS		Hikoshima
CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X and Hb A can be separated at alkaline pH; the slow-moving variant has a mobility like Hb S; no separation at acidic pH
CHROMATOGRAPHY		Hb X was isolated on an Amberlite IRC-50 column
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation CAA->CGA; alpha2 or alpha1
FUNCTIONAL STUDIES		Normal
STABILITY		Normal
OCCURRENCE		Found in a Japanese family
OTHER INFORMATION		Quantity in heterozygotes 13-20%

REFERENCES
1.		Miyaji, T., Iuchi, I., Takeda, I., and Shibata, S.: Acta Haematol. Jpn., 26:531, 1963.
2.		Hanada, M. and Rucknagel, D.L.: Blood, 24:624, 1964.
3.		Imai, K., Morimoto, H., Kotani, M., Shibata, S., Miyaji, T., and Matsutomo, K.: Biochim. Biophys. Acta, 200:197, 1970.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.