Hb Reims alpha23(B4)Glu->Gly
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X moves slower than Hb A at alkaline pH; good separation by IEF
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting on an HPLC column; amino acid analysis; sequencing of the alphaT-4 peptide
DNA ANALYSES Not reported; presumed mutation GAG->GGG; alpha2 or alpha1
STABILITY Slightly unstable
OCCURRENCE Found in a 60-year-old French woman
OTHER INFORMATION Quantity in the heterozygote ~31%
1. Bardakdjian-Michau, J., Rosa, J., Galactéros, F., Lancelot, M., and Marquart, F.X.: Hemoglobin, 13:733, 1989.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.