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ALSO KNOWN AS | |
Ogi | |
CONTACT | |
alpha1beta1 contact | |
HEMATOLOGY | |
Normal in the heterozygote | |
ELECTROPHORESIS | |
Hb X separates from Hb A as a slowly-moving variant at alkaline pH; it also separates from Hb A at acidic pH; moves between Hb S and Hb F on cellulose acetate and starch gel; moves between Hb A and Hb S on agar gel | |
CHROMATOGRAPHY | |
Hb X was isolated on a DEAE-cellulose column | |
STRUCTURE STUDIES | |
Tryptic digestion; separation of peptides by fingerprinting or reversed phase HPLC; amino acid analysis | |
DNA ANALYSES | |
Not reported; presumed mutation CTG->CGG; alpha2 or alpha1 | |
FUNCTIONAL STUDIES | |
Slightly increased oxygen affinity; normal Bohr effect and cooperativity | |
STABILITY | |
Mildly unstable | |
OCCURRENCE | |
Found in Korean, Chinese, Japanese, Vietnamese, and Thai families | |
OTHER INFORMATION | |
Quantity in heterozygotes 10-16% | |
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REFERENCES |
1. | |
Tatsis, B.: Blood, 54:61a (Suppl. 1), 1979. | |
2. | |
Zeng, Y-T., Huang, S-Z., Yen, Y-K., Li, W-C., Lam, H., Webber, B., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 6:209, 1982. | |
3. | |
Sugihara, J., Imamura, T., Yamada, H., Imoto, T., Matsuo, T., Sumida, I., and Yanase, T.: Biochim. Biophys. Acta, 701:45, 1982. | |
4. | |
Yongsuwan, S., Svasti, J., and Fucharoen, S.: Hemoglobin, 11:567, 1987. | |