Hb O-Padova alpha30(B11)Glu->Lys
CONTACT alpha1beta1 contact
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X moves between Hb S and Hb C (closer to Hb C) on starch gel, cellulose acetate, and citrate agar at alkaline pH
CHROMATOGRAPHY Hb X was isolated on a DEAE-Sephadex or DEAE-cellulose column
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting or on a reversed phase column; amino acid analysis
DNA ANALYSES Not reported; presumed mutation GAG->AAG; alpha2 or alpha1
OCCURRENCE Found in members of an Italian and a Turkish family
OTHER INFORMATION Quantity in heterozygotes 12.6-18%
1. Vettore, L., DeSandre, G., Dilorio, E.E., Winterhalter, K.H., Lang, A., and Lehmann, H.: Blood, 44:869, 1974.
2. Kilinç, Y., Kumi, M., Gurgey, A., Altay, Ç., Webber, B.B., Wilson, J.B., Kutlar, A., and Huisman, T.H.J.: Hemoglobin, 9:621, 1985.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.