Hb Nunobiki alpha141(HC3)Arg->Cys
CONTACT C-terminus
HEMATOLOGY Mild erythrocytosis in the heterozygote
ELECTROPHORESIS IEF showed discrete bands of Hb X, Hb A, and Hb A2, in that order
CHROMATOGRAPHY Hb X and Hb A separate on a DEAE-cellulose column
STRUCTURE STUDIES Tryptic digestion of alphaX chain; separation of peptides; amino acid analysis
DNA ANALYSES Not reported; presumed mutation CGT->TGT; alpha2 or alpha1
FUNCTIONAL STUDIES Increased oxygen affinity
OCCURRENCE Found in a Japanese male
OTHER INFORMATION Quantity in the heterozygote 13%; the cysteine residue does not participate in inter- or intra-molecular disulfide formation
1. Shimasaki, S.: J. Clin. Invest., 75:695, 1985.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.