Hb Miyano alpha41(C6)Thr->Ser
CONTACT Internal; alpha1beta2 contact
HEMATOLOGY Erythrocytosis in the heterozygote
ELECTROPHORESIS Separation of Hb X and Hb A only by IEF
CHROMATOGRAPHY Hb X and Hb A could not be separated by either anion or cation exchange HPLC
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting on a cation exchange HPLC column; amino acid analysis; acid hydrolysis of the alphaT-6 peptide
DNA ANALYSES Not reported; presumed mutation ACC->TCC or AGC; alpha2 or alpha1
FUNCTIONAL STUDIES Increased oxygen affinity
OCCURRENCE Found in a Japanese male blood donor, born in 1931
1. Ohba, Y., Imai, K., Uenaka, R., Ami, M., Fujisawa, K., Itoh, K., Hirakawa, K., and Miyaji, T.: Hemoglobin, 13:637, 1989.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.