Hb Memphis alpha23(B4)Glu->Gln
CONTACT External
HEMATOLOGY Not reported
ELECTROPHORESIS Hb X moves to the position of Hb S at both alkaline and acidic pH; it moves slightly cathodal to Hb S on agar gel at pH 6.2 and 7.2
CHROMATOGRAPHY Not studied in detail
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES Not reported; presumed mutation GAG->CAG; alpha2 or alpha1
STABILITY Not reported
OCCURRENCE Found in a few Black families
OTHER INFORMATION Found in combination with Hb S and Hb C; combination with the Hb S condition might be milder than the common sickle cell anemia
1. Kraus, A.P., Miyaji, T., Iuchi, I., and Kraus, L.M.: J. Lab. Clin. Med., 66:886, 1965.
2. Kraus, L.M., Miyaji, T., Iuchi, I., and Kraus, A.P.: Biochemistry, 5:3701, 1966.
3. Cooper, M.R., Kraus, A.P., Felts, J.H., Ramseur, W.L., Myers, R., and Kraus, L.P.: Am. J. Med., 55:535, 1973.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.