Hb Luxembourg alpha24(B5)Tyr->His
CONTACT Internal
HEMATOLOGY Mild hemolysis; reticulocytosis; no anemia in the heterozygote
ELECTROPHORESIS Hb X migrates with a pI similar to Hb A1c on IEF
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting on an HPLC column; amino acid analysis
DNA ANALYSES Not reported; presumed mutation TAT->CAT; alpha2 or alpha1
STABILITY Slightly unstable
OCCURRENCE Found in two Dutch families
OTHER INFORMATION Quantity in the heterozygote estimated at 20-22%
1. Groff, P., Galacteros, F., Kalmes, G., Blouquit, Y., and Wajcman, H.: Hemoglobin, 13:429, 1989.
2. Moo-Penn, W.F., Hine, T.K., Johnson, M.H., Jue, D.L., Piersma, H., Therrell, B., Jr., and Chu, A.: Hemoglobin, 15:97, 1991.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.