Hb Loire alpha88(F9)Ala->Ser
CONTACT Internal
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS No separation of Hb X and Hb A by routine electropho-retic methods; it focuses between Hb A and Hb F (near Hb F) on IEF
STRUCTURE STUDIES Hb X was isolated by preparative IEF; the alphaX and beta chains were separated by CM-cellulose chromatography; the tryptic peptides were separated by reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES Not reported; presumed mutation GCG->TCG; alpha2 or alpha1
FUNCTIONAL STUDIES Increased oxygen affinity
STABILITY More stable than Hb A
OCCURRENCE Found in a family of Algerian-French descent
OTHER INFORMATION Quantity in heterozygotes 25-30%
1. Baklouti, F., Baudin-Chich, V., Kister, J., Marden, M., Teyssier, G., Poyart, C., Delaunay, J., and Wajcman, H.: Eur. J. Biochem., 177:307, 1988.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.