Hb Legnano alpha141(HC3)Arg->Leu
CONTACT C-terminus
HEMATOLOGY Erythrocytosis in the heterozygote
ELECTROPHORESIS Hb X moves ahead of Hb A on cellulose acetate at alkaline pH
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; sequencing
DNA ANALYSES Not reported; presumed mutation CGT->CTT; alpha2 or alpha1
FUNCTIONAL STUDIES Increased oxygen affinity; decreased cooperativity and Bohr effect
STABILITY Slightly unstable
OCCURRENCE Found in members of an Italian family
OTHER INFORMATION Quantity in the heterozygote 32-35%
1. Mavilio, F., Marinucci, M., Tentori, L., Fontanarosa, P.P., Rossi, U., and Biagiotti, S.: Hemoglobin, 2:249, 1978.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.