Hb Kawachi alpha44(CE2)Pro->Arg
CONTACT External
HEMATOLOGY Not reported
ELECTROPHORESIS Hb A and Hb X separate at alkaline pH; Hb X is present between Hb A2 and Hb A on IEF
CHROMATOGRAPHY Hb X was isolated on a DEAE-cellulose column
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES Not reported; presumed mutation CCG->CGG; alpha2 or alpha1
FUNCTIONAL STUDIES Increased oxygen affinity, reduced Bohr effect and cooperativity
OCCURRENCE Found in three members of a Japanese family
OTHER INFORMATION Quantity in heterozygotes 26-27%
1. Harano, T., Harano, K., Ueda, S., Shibata, S., Imai, K., Ohba, Y., Shinohara, T., Horio, S., Nishioka, K., and Shirotani, H.: Hemoglobin, 6:43, 1982.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.