Hb Jackson alpha127(H10)Lys->Asn
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X moves to the position of Hb J-Baltimore at alkaline pH
CHROMATOGRAPHY Hb X was isolated by DEAE-Sephadex or DEAE-cellulose chromatography
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting or cation exchange chromatography; chymotrypsin; amino acid analysis; sequen-cing; carboxypeptidase C; aminopeptidase M; chymotryptic digestion of the oxidized core
DNA ANALYSES Not reported; presumed mutation AAG->AAT or AAC; alpha2 or alpha1
OCCURRENCE Found in a few Black families from the Southeastern USA
OTHER INFORMATION Quantity in the heterozygote 20-25%
1. Moo-Penn, W.F., Bechtel, K.C., Johnson, M.H., Jue, D.L., Holland, S., Huff, C., and Schmidt, R.M.: Am. J. Clin. Pathol., 66:453, 1976.
2. Lam, H., Webber, B.B., Wilson, J.B., and Huisman, T.H.J.: J. Chromatogr., 269: 119, 1983.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.