Hb J-Toronto alpha5(A3)Ala->Asp
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Separates as a fast-moving Hb J from Hb A at alkaline pH
CHROMATOGRAPHY Hb X can be separated from Hb A by cation and anion exchange chromatography
STRUCTURE STUDIES Hb X was identified by fingerprinting; amino acid analysis
DNA ANALYSES Not reported; presumed mutation GCC->GAC; alpha2 or alpha1
OCCURRENCE In two English families
OTHER INFORMATION Quantity in heterozygotes 25-35%
1. Crookston, J.H., Beale, D., Irvine, D., and Lehmann, H.: Nature, 208:1059, 1965.
2. Vella, F., Hill, J.R., Wiltshire, B., and Lehmann, H.: Clin. Biochem., 4:137, 1971.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.