Hb J-Rajappen alpha90(FG2)Lys->Thr
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X moves to the position of Hb J at alkaline pH
CHROMATOGRAPHY Hb A and Hb X separate by cation and anion exchange HPLC
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; reversed phase HPLC; amino acid analysis; DNA sequencing
DNA ANALYSES An AAG->ACG mutation at codon 90 in the alpha1-globin gene (Ref. 2)
OCCURRENCE Found in members of Indian families
OTHER INFORMATION Quantity in the heterozygote 19.5-20.5% (Ref. 2)
1. Hyde, R.D., Kinderlerer, J.L., Lehmann, H., and Hall, M.D.: Biochim. Biophys. Acta, 243: 515, 1971.
2. Molchanova, T.P., Pobedimskaya, D.D., and Huisman, T.H.J.: Br. J. Haematol., 88:300, 1994.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.